Adapalene 0.1% / Benzoyl Peroxide 2.5% + Doxycycline 200mg Is A Less Expensive Alternative Compared to Oral Isotretinoin for The Management of Severe Nodular Acne In Sweden

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Fixed-Dose Combination Gel of Adapalene and Benzoyl Peroxide plus Doxycycline 100 mg versus Oral Isotretinoin for the Treatment of Severe Acne: Efficacy and Cost Analysis.

BACKGROUND Acne vulgaris is a chronic skin disease with a high prevalence. Left untreated or inadequately treated, acne vulgaris can lead to psychological and physical scarring, as well as to unnecessary medical expenses. Oral isotretinoin is an effective treatment for severe resistant nodular and conglobate acne vulgaris. A regimen consisting of a fixed-dose combination of adapalene and benzoy...

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Is less more with isotretinoin and acne?

Evidence • Three RCTs compared conventional with low dosing. -For 24 weeks, 60 patients with moderate acne used low (0.25 to 0.4 mg/kg daily) or conventional doses (0.5 to 0.7 mg/kg daily).1 The low-dose group showed equivalent efficacy (acne grading and lesion counts); increased patient satisfaction (76% very satisfied vs 31%); and a higher (non-significant) 1-year relapse rate (18% vs 13%). -...

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Efficacy and tolerability of adapalene 0.1%-benzoyl peroxide 2.5% combination gel in treatment of acne vulgaris in Indian patients: A randomized investigator-blind controlled trial

Background: Topical retinoid based combinations are recommended to enhance the outcome of acne treatment. Adapalene-benzoyl peroxide (BPO) combination gel was approved in 2009 for acne treatment. The aim of this study was to evaluate the efficacy and tolerability of adapalene 0.1%-benzoyl peroxide 2.5% combination gel compared to adapalene 0.1% gel monotherapy and benzoyl peroxide 2.5% gel mono...

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Acne Subject Preference for Pump Over Tube for Dispensing Fixed-Dose Combination Adapalene 0.1%–Benzoyl Peroxide 2.5% Gel

INTRODUCTION Acne is a chronic inflammatory disease. Key to a patient's success on fixed-dose adapalene-benzoyl peroxide (BPO) gel is ensuring adherence. Use of a pump system to deliver a pre-measured amount of gel with each pressure enables application of a more consistent dose vs. the tube, which should improve adherence. In the present study, we evaluate patient preference for two different ...

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ژورنال

عنوان ژورنال: Value in Health

سال: 2015

ISSN: 1098-3015

DOI: 10.1016/j.jval.2015.09.567